1. the disgrace or the reproach incurred by conduct considered outrageously shameful; infamy.
2. a cause or object of such disgrace or reproach.
3. fall from grace; ignominy.
Etymology: first attested 1656, from Latin opprobrium, “reproach, disgrace”, from opprōbrō, “reproach, taunt”, from ob, “against” + probrum, “disgrace, dishonour”.
[Chris Rahn - Fallen Angel]